Between about 2:34 PM and 3:51 PM ET US, there looked to have been a partial networking outage related to WebTitan  / SpamTitan servers in AWS Region us-east-2 (Ohio).

[RESOLVED] Internet Connectivity

[01:06 PM PST] Between 11:34 AM and 12:51 PM PST, customers experienced Internet connectivity issues for some networks to and from the US-EAST-2 Region. Connectivity between instances within the Region, in between Regions, and Direct Connect connectivity were not impacted by this issue. The issue has been resolved and connectivity has been fully restored.

AWS Network Outage on 2022-12-05